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Rationally Engineering Phototherapy Modules of Eosin-Conjugated Responsive Polymeric Nanocarriers via Intracellular Endocytic pH Gradients
journal contribution
posted on 2015-12-17, 08:41 authored by Guhuan Liu, Jinming Hu, Guoying Zhang, Shiyong LiuSpatiotemporal
switching of respective phototherapy modes at the
cellular level with minimum side effects and high therapeutic efficacy
is a major challenge for cancer phototherapy. Herein we demonstrate
how to address this issue by employing photosensitizer-conjugated
pH-responsive block copolymers in combination with intracellular endocytic
pH gradients. At neutral pH corresponding to extracellular and cytosol
milieu, the copolymers self-assemble into micelles with prominently
quenched fluorescence emission and low 1O2 generation
capability, favoring a highly efficient photothermal module. Under
mildly acidic pH associated with endolysosomes, protonation-triggered
micelle-to-unimer transition results in recovered emission and enhanced
photodynamic 1O2 efficiency, which synergistically
actuates release of encapsulated drugs, endosomal escape, and photochemical
internalization processes.
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encapsulated drugsinternalization processesIntracellular Endocytic pH GradientsSpatiotemporalintracellular endocytic pH gradientsphototherapy modesphotothermal modulecopolymersRationally Engineering Phototherapy Modulescancer phototherapy1 O 2 generation capabilityquenched fluorescence emissioncytosol milieusynergistically actuates releaseacidic pHside effectsphotodynamic 1 O 2 efficiency
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