Rapid Synthesis of CDP840 with
2-Pyrimidyl Vinyl Sulfide as a Platform

Muraoka, Nobuhiro; Mineno, Masahiro; Itami, Kenichiro; Yoshida, Jun-ichi

doi:10.1021/jo0510437.s001

jo0510437_si_001.pdf (1.47 MB)

Rapid Synthesis of CDP840 with 2-Pyrimidyl Vinyl Sulfide as a Platform

journal contribution

posted on 2005-08-19, 00:00 authored by Nobuhiro Muraoka, Masahiro Mineno, Kenichiro Itami, Jun-ichi Yoshida

A rapid synthesis of CDP840 (a potential therapeutic agent for asthma), using 2-pyrimidyl vinyl sulfide as a platform, has been established. This method includes a stereoselective double Mizoroki−Heck-type arylation, a Liebeskind−Srogl-type cross-coupling reaction, and a Pd/C-catalyzed hydrogenation.