Rapid Synthesis of CDP840 with 2-Pyrimidyl Vinyl Sulfide as a Platform

A rapid synthesis of CDP840 (a potential therapeutic agent for asthma), using 2-pyrimidyl vinyl sulfide as a platform, has been established. This method includes a stereoselective double Mizoroki−Heck-type arylation, a Liebeskind−Srogl-type cross-coupling reaction, and a Pd/C-catalyzed hydrogenation.