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Raman and Computational Study on the Adsorption of Xanthine on Silver Nanocolloids
journal contribution
posted on 2018-10-18, 17:03 authored by Francesco Muniz-Miranda, Alfonso Pedone, Maurizio Muniz-MirandaXanthine
is a nucleobase, deriving from adenine and guanine by
deamination and oxidation processes, which may deposit in the human
body causing diseases, similar to uric acid. Here, we have investigated
the adsorption of xanthine on silver colloidal nanoparticles by means
of surface-enhanced Raman scattering (SERS) with an exciting radiation
in the near-infrared spectral region, where interference due to fluorescence
does not occur, along with density functional theory calculations
of molecule/metal model systems. By adopting a combined experimental
and computational approach, we have identified the “marker”
SERS bands of xanthine and the tautomer that preferentially binds
the silver particles, as well as the molecular group involved in the
interaction with metal. This investigation allows using the FT-SERS
spectroscopy for biosensory and diagnostic purposes in body fluids,
detecting abnormal levels of xanthine, and preventing metabolic diseases.