American Chemical Society
Browse
np9b00260_si_003.cif (371.31 kB)

Pyrimidine Nucleosides from Streptomyces sp. SSA28

Download (371.31 kB)
dataset
posted on 2019-08-22, 14:36 authored by Cheng-Dong Xu, Hao-Jian Zhang, Zhong-Jun Ma
Eleven new pyrimidine nucleosides (111) and 12 known analogues (1223) were isolated from the marine-derived Streptomyces sp. SSA28. All of the new structures were elucidated by extensive NMR spectroscopic analysis and HRESIMS data. The absolute configurations of compound 1 were determined by X-ray diffraction. The configurations of 216 were investigated by ECD calculations. Compounds 1116 showed cytotoxicity against HCT-116 human colon cancer cell lines with IC50 values from 0.39 ± 0.03 to 6.63 ± 0.47 μM.

History