ol6b03745_si_002.cif (5.22 MB)
Pyrazolofluostatins A–C, Pyrazole-Fused Benzo[a]fluorenes from South China Sea-Derived Micromonospora rosaria SCSIO N160
dataset
posted on 2017-01-11, 18:53 authored by Wenjun Zhang, Chunfang Yang, Chunshuai Huang, Liping Zhang, Haibo Zhang, Qingbo Zhang, Cheng-shan Yuan, Yiguang Zhu, Changsheng ZhangPyrazolofluostatins
A–C (1–3), three new benzo[a]fluorenes with an unprecedented
carbon skeleton, were obtained from the South China Sea-derived Micromonospora rosaria SCSIO N160. Their structures were
elucidated by extensive spectroscopic analyses. The structure of pyrazolofluostatin
A (1) was confirmed by X-ray crystallographic analysis.
Notably, 1–3 possessed a benzo[cd]indeno[2,1-f]indazol skeleton with a
pyrazole-fused 6/5/6/6/5 pentacyclic ring system. Pyrazolofluostatin
A (1) showed moderate antioxidation activity (EC50 48.6 μM).