ja9b13484_si_001.pdf (8.86 MB)
Prophylactic Antiviral Activity of Sulfated Glycomimetic Oligomers and Polymers
journal contribution
posted on 2020-03-10, 15:37 authored by Laura Soria-Martinez, Sebastian Bauer, Markus Giesler, Sonja Schelhaas, Jennifer Materlik, Kevin Janus, Patrick Pierzyna, Miriam Becker, Nicole L. Snyder, Laura Hartmann, Mario SchelhaasIn
this work, we investigate the potential of highly sulfated synthetic
glycomimetics to act as inhibitors of viral binding/infection. Our
results indicate that both long-chain glycopolymers and short-chain
glycooligomers are capable of preventing viral infection. Notably,
glycopolymers efficiently inhibit Human Papillomavirus (HPV16) infection
in vitro and maintain their antiviral activity in vivo, while the
glycooligomers exert their inhibitory function post attachment of
viruses to cells. Moreover, when we tested the potential for broader
activity against several other human pathogenic viruses, we observed
broad-spectrum antiviral activity of these compounds beyond our initial
assumptions. While the compounds tested displayed a range of antiviral
efficacies, viruses with rather diverse glycan specificities such
as Herpes Simplex Virus (HSV), Influenza A Virus (IAV), and Merkel
Cell Polyomavirus (MCPyV) could be targeted. This opens new opportunities
to develop broadly active glycomimetic inhibitors of viral entry and
infection.