ol006679t_si_002.pdf (141.09 kB)
Progress toward the Total Synthesis of Callipeltin A (I): Asymmetric Synthesis of (3S,4R)-3,4-Dimethylglutamine
journal contribution
posted on 2000-12-02, 00:00 authored by Bo Liang, Patrick J. Carroll, Madeleine M. JoulliéDuring the total synthesis of the novel cyclic depsipeptide callipeltin A (1), the unit (3S,4R)-3,4-dimethylglutamine, was successfully synthesized
by asymmetric Michael addition and subsequent electrophilic azidation. The key feature of this approach is the generation of three adjacent
stereogenic centers using the same camphorsultam chiral auxiliary.