Probing the Diastereotopicity of Methylene Protons in Strychnine Using Residual Dipolar Couplings

2003-02-04T00:00:00Z (GMT) by Christina M. Thiele Stefan Berger
Residual dipolar couplings were successfully used to distinguish between the two diastereotopic protons on C-20 of strychnine dissolved in an organic liquid crystal (PBLG/CDCl3). The results presented here strongly suggest that this method will be of help in organic structure determination, making the determination of relative stereochemistry in the absence of NOE data possible.