ol0487130_si_001.pdf (25.71 kB)
Preparation of Tertiary Amides from Carbamoyl Chlorides and Organocuprates
journal contribution
posted on 2004-10-14, 00:00 authored by Laurent Lemoucheux, Thomas Seitz, Jacques Rouden, Marie-Claire LasneReaction of carbamoyl chlorides with cyano-Gilman cuprates affords tertiary amides in good to excellent yields. The reaction is general due
to the possibility of using reagents made either from organolithium or from Grignard compounds. The characterization of the main side
products allowed for the suggestion of a possible mechanism.