posted on 2020-03-20, 17:51authored byJing-ran Fan, Yi Kuang, Ze-yuan Dong, Yang Yi, Yan-xia Zhou, Bin Li, Xue Qiao, Min Ye
Glycyrrhiza uralensis (liquorice) is a well-known
medicinal plant. Its roots and rhizomes are used as the popular Chinese
herbal medicine Gan-Cao. An ethanol extract of the aerial parts of G. uralensis showed antidiabetic effects on db/db mice.
It decreased the blood glucose level by 30.3% and increased the serum
insulin level by 41.8% compared to the control group. Eighty-six phenolic
compounds (1-86) were obtained from the
aerial parts, including the new prenylated isoflavanones (1–5), isoflavans (6–9), and a 2-phenylbenzofuran (10). The structures
were identified by NMR and HRESIMS data analyses, and the absolute
configurations were established by comparing the calculated and experimental
ECD spectroscopic data. Compounds 2, 6,
and 10 inhibited PTP1B with IC50 values of
5.9, 6.7, and 5.3 μM, respectively. Compound 2 and
the known compounds glycycoumarin (76) and glyurallin
A (79) inhibited α-glucosidase with IC50 values of 20.1, 0.1, and 0.3 μM, respectively. Compound 4 at 10 μM increased the glucose uptake rate to 95%
in an insulin resistance HepG2 cell model (p <
0.01).