bc0c00030_si_001.pdf (971.73 kB)
Potential Therapeutic Application of Zinc Oxide Nanoflowers in the Cerebral Ischemia Rat Model through Neuritogenic and Neuroprotective Properties
Version 2 2020-02-25, 14:42
Version 1 2020-02-24, 20:33
journal contribution
posted on 2020-02-25, 14:42 authored by Ayan Kumar Barui, Priya Jhelum, Susheel Kumar Nethi, Tapatee Das, Dwaipayan Bhattacharya, Vinothkumar B, Shailaja Karri, Sumana Chakravarty, Chitta Ranjan PatraNeuritogenesis, a
complex process of the sprouting of neurites, plays a vital role in
the structural and functional restoration of cerebral ischemia-injured
neuronal tissue. Practically, there is no effective long-term treatment
strategy for cerebral ischemia in clinical practice to date due to
several limitations of conventional therapies, facilitating the urgency
to develop new alternative therapeutic approaches. Herein, for the
first time we report that pro-angiogenic nanomaterials, zinc oxide
nanoflowers (ZONF), exhibit neuritogenic activity by elevating mRNA
expression of different neurotrophins, following PI3K/Akt-MAPK/ERK
signaling pathways. Further, ZONF administration to global cerebral
ischemia-induced Fischer rats shows improved neurobehavior and enhanced
synaptic plasticity of neurons via upregulation of Neurabin-2 and
NT-3, revealing their neuroprotective activity. Altogether, this
study offers the basis for exploitation of angio-neural cross talk
of other pro-angiogenic nano/biomaterials for future advancement of
alternative treatment strategies for cerebral ischemia, where neuritogenesis
and neural repair are highly critical.
History
Usage metrics
Categories
Keywords
ischemia-injuredpro-angiogenic nanomaterialstreatment strategypracticetherapymRNA expressionalternative treatment strategieszinc oxide nanoflowersZinc Oxide NanoflowersZONF administrationapproachneurobehaviorNeuroprotective Properties Neuritogenesisneurotrophinlimitationsynaptic plasticityangio-neuralneuritogenicneuroprotective activityneuritebasisNTPotential Therapeutic ApplicationneuritogenesiNeuritogenictissuePI 3KexhibitNeurabin -2neuronfuture advancementHereinupregulationexploitationischemia-induced Fischer ratsrolepathwayrestorationCerebral Ischemia Rat Modelurgency
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC