cm402614k_si_001.pdf (2.07 MB)
Polymer–Liposome Complexes with a Functional Hydrogen-Bond Cross-Linker for Preventing Protein Adsorption and Improving Tumor Accumulation
journal contribution
posted on 2013-11-12, 00:00 authored by Yi-Ting Chiang, Yung-Ting Cheng, Chih-Yang Lu, Yu-Wei Yen, Lu-Yi Yu, Kun-Siou Yu, Sih-Ying Lyu, Chieh-Yu Yang, Chun-Liang LoTo
solve biostability and organ distribution problems in polymer-coated
liposomes, this study developed tumor–extracellular matrix
pH-induced targeting polymer–liposome complexes (ECM-targeting
liposomes) that are highly stable in a protein-rich environment and
can trigger targeting ability in tumor ECM environment. Experimental
results show that the ECM-targeting liposomes significantly reduced
adsorption of various proteins (HSA, IgG, and fibrinogen) and leakage
of encapsulated drug doxorubicin–hydrochloride from liposomes,
significantly improved uptake efficiency in HCT116 colon cancer cells,
improved HCT116 tumor accumulation, and reduced distribution in normal
organs (e.g., liver, spleen, lung, etc.). We demonstrate that ECM-targeting
liposomes overcome the limitations of conventional liposomes and stealth
liposomes in cancer therapy.