mp9b01070_si_001.pdf (834.98 kB)
Polydopamine-Encapsulated Perfluorocarbon for Ultrasound Contrast Imaging and Photothermal Therapy
journal contribution
posted on 2020-02-18, 22:43 authored by Jinjin Zhu, Zhu Wang, Xiaolin Xu, Ming Xu, Xi Yang, Chunyang Zhang, Jie Liu, Fan Zhang, Xintao Shuai, Wei Wang, Zhong CaoBiomedical nanoplatforms have been
widely investigated for ultrasound
(US) imaging and cancer therapy. Herein, perfluorocarbon (PFC) is
encapsulated into biocompatible polydopamine (PDA) to form a theranostic
nanosystem, followed by the modification of polyethylene glycol (PEG)
to stabilize the nanoparticle via a facile one-pot method. Under 808
nm near-infrared laser irradiation, PDA can generate hyperthermia
to transform PFC droplets to bubbles with high US imaging sensitivity.
The US imaging detection of the PFC-PDA-PEG nanosystem is achievable
in a time span of up to 25 min in vitro at a low US frequency and
mechanical index, manifesting a US imaging performance for in vivo
application. Moreover, tumor cells incubated with the nanosystem are
ablated effectively under laser irradiation at 808 nm. The results
illustrate the potential of the PDA-based theranostic agent in US
imaging-guided photothermal therapy of tumor.
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imaging-guided photothermal therapyimaging performanceimaging detectionvivo application25 minlaser irradiationimaging sensitivity808 nm near-infrared laser irradiationtheranostic nanosystembiocompatible polydopaminetumor cellsPFC dropletsone-pot methodPolydopamine-Encapsulated Perfluorocarbonpolyethylene glycolPFC-PDA-PEG nanosystem808 nmUltrasound Contrast ImagingPDA-based theranostic agenttime spancancer therapyPhotothermal Therapy Biomedical nanoplatforms
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