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Poly(iohexol) Nanoparticles As Contrast Agents for in Vivo X‑ray Computed Tomography Imaging
journal contribution
posted on 2013-09-18, 00:00 authored by Qian Yin, Felix
Y. Yap, Lichen Yin, Liang Ma, Qin Zhou, Lawrence W. Dobrucki, Timothy M. Fan, Ron C. Gaba, Jianjun ChengBiocompatible
poly(iohexol) nanoparticles, prepared through cross-linking
of iohexol and hexamethylene diisocyanate followed by coprecipitation
of the resulting cross-linked polymer with mPEG-polylactide, were
utilized as contrast agents for in vivo X-ray computed tomography
(CT) imaging. Compared to conventional small-molecule contrast agents,
poly(iohexol) nanoparticles exhibited substantially protracted retention
within the tumor bed and a 36-fold increase in CT contrast 4 h post
injection, which makes it possible to acquire CT images with improved
diagnosis accuracy over a broad time frame without multiple administrations.