posted on 2020-03-10, 20:14authored byLisa Marie Kammer, Matthias Krumb, Benjamin Spitzbarth, Benjamin Lipp, Jonas Kühlborn, Jonas Busold, Olga M. Mulina, Alexander O. Terentev, Till Opatz
The one-pot sulfonylation/aminoalkylation
of styrene derivatives
furnishing substituted γ-sulfonylamines was accomplished through
a photoredox-catalyzed four-component reaction. Besides one molecule
of water and the sodium counterion of the sulfinate, all atoms of
the starting materials are transferred to the final product, rendering
this process highly atom-efficient. The operationally simple protocol
allows for the simultaneous formation of three new single bonds (C–S,
C–N, and C–C) and therefore grants rapid access to structurally
diverse products.