ja066692u_si_001.pdf (4.97 MB)
Photoinduced Signal Amplification through Controlled Externally Sensitized Fragmentation in Masked Sensitizers
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posted on 2006-11-22, 00:00 authored by Rudresha Kottani, Janaki R. R. Majjigapu, Alexei Kurchan, Kavitha Majjigapu, Tiffany P. Gustafson, Andrei G. KutateladzeAddition of lithiated dithianes to diaryl ketones, potential electron-transfer sensitizers, disrupts conjugation between the two aromatic moieties, effectively masking the sensitizer. A novel photoamplification strategy is developed based on photosensitized cleavage in such adducts, where each fragmentation event releases more diaryl ketone, capable of sensitization. As a result, mass release of dithianes, triggered with a very small amount of the initiator, is observed. Such amplified release can be made contingent on a molecular recognition event, offering a promising methodology for high throughput bioanalytical applications. The concept is proved with the use of micro- and nanosized polymeric supports, including dendrimers.
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diaryl ketoneMasked SensitizersAdditionnovel photoamplification strategysensitizerdiaryl ketonesthroughput bioanalytical applicationsControlled Externally Sensitized Fragmentationmass releaserecognition eventPhotoinduced Signal Amplificationfragmentation event releasesphotosensitized cleavagelithiated dithianes
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