Phosphine-Catalyzed Highly Enantioselective [3 + 3] Cycloaddition of Morita–Baylis–Hillman Carbonates with C,N-Cyclic Azomethine Imines
2015-04-08T00:00:00Z (GMT)
by
The first phosphine-catalyzed highly
enantioselective [3 + 3] cycloaddition
of Morita–Baylis–Hillman carbonates with C,N-cyclic
azomethine imines is described. Using a spirocyclic chiral phosphine
as the catalyst, a novel class of pharmaceutically interesting 4,6,7,11b-tetrahydro-1<i>H</i>-pyridazino[6,1-<i>a</i>]iso-quinoline
derivatives were obtained in high yields with good to excellent diastereoselectivities
and extremely excellent enantioselectivities (98–>99% ee).
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