jo061218s_si_001.pdf (368.01 kB)
Phosphine-Catalyzed Allylic Substitution of Morita−Baylis−Hillman Acetates: Synthesis of N-Protected β-Aminophosphonic Acid Esters
journal contribution
posted on 2006-09-29, 00:00 authored by HaeIl Park, Chang-Woo Cho, Michael J. KrischeA series of N-protected β-amino phosphonic acid esters have
been prepared by phosphine-catalyzed allylic substitution of
2-(diethylphosphonyl)-substituted allylic acetates employing
4,5-dichlorophthalimide as nucleophilic partner. These organocatalytic allylic substitutions exhibit exceptionally high
levels of regiospecificity by virtue of a tandem SN2‘−SN2‘
mechanism.