ol6b00214_si_004.cif (379.35 kB)
Phomopchalasins A and B, Two Cytochalasans with Polycyclic-Fused Skeletons from the Endophytic Fungus Phomopsis sp. shj2
dataset
posted on 2016-02-16, 00:00 authored by Bing-Chao Yan, Wei-Guang Wang, Dong-Bao Hu, Xiang Sun, Ling-Mei Kong, Xiao-Nian Li, Xue Du, Shi-Hong Luo, Yan Liu, Yan Li, Han-Dong Sun, Jian-Xin PuPhomopchalasins A (1) and B (2), two
novel cytochalasans with unprecedented carbon skeletons, and phomopchalasin
C (3), containing a rare hydroperoxyl motif, were obtained
from the endophytic fungus Phomopsis sp. shj2, which
was first isolated from the Isodon eriocalyx var. laxiflora. Their structures were elucidated by extensive spectroscopic analyses,
electronic circular dichroism (ECD) calculation, and X-ray crystallographic
analysis. Notably, 1 possessed an unprecedented 5/6/5/8-fused
tetracyclic ring system, and 2 featured a novel 5/6/6/7/5-fused
pentacyclic skeleton. The cytotoxic, anti-inflammatory, and antimigratory
activities of 1–3 were evaluated
in vitro.
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novel cytochalasanscalculationcarbon skeletonsantimigratory activitiesEndophytic Fungus Phomopsis sptetracyclic ring systemECDIsodon eriocalyx vardichroismcytotoxiclaxifloraphomopchalasinspectroscopic analysesSkeletonendophytic fungus Phomopsis spshj 2Phomopchalasinsanalysishydroperoxyl motifpentacyclic skeletonCytochalasan
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