Phenolic Glycosides with Antioxidant Activity from the Stem Bark of Populus davidiana

Phytochemical study on the EtOAc-soluble fraction of the stem bark of Populus davidiana resulted in the isolation of 10 phenolic glycosides (1−10), which were identified on the basis of physicochemical and spectroscopic analyses. Among these, three new compounds, populosides A−C (1−3), were determined to be 2-coumaroylmethyl-4-hydroxyphenyl-β-d-glucopyranoside, 2-coumaroylmethylphenyl-β-d-glucopyranoside, and 2-feruoylmethylphenyl-β-d-glucopyranoside, respectively. Compounds 1−10 were tested for their radical scavenging activity against an azo radical, ABTS^•+. Of these, populosides A−C (1−3), populoside (4), grandidentatin (8), salireposide (9), and coumaroyl-β-d-glucoside (10) exhibited antioxidant activity in this assay.