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Phase-Shifted PFH@PLGA/Fe3O4 Nanocapsules for MRI/US Imaging and Photothermal Therapy with near-Infrared Irradiation
journal contribution
posted on 2015-07-08, 00:00 authored by Yajing Zhao, Weixiang Song, Dong Wang, Haitao Ran, Ronghui Wang, Yuanzhi Yao, Zhigang Wang, Yuanyi Zheng, Pan LiPhotothermal therapy (PTT) utilizes
photothermal conversion reagents
to generate heat energy from absorbed light to effectively treat various
malignant diseases. This approach has attracted broad and increasing
interest in cancer treatment. Near-infrared (NIR)-induced PTT is particularly
attractive because of its minimal absorbance by normal tissue and
relatively deep tissue penetration. To improve the efficacy of PTT,
we have developed nanocapsules encapsulating superparamagnetic iron
oxide (Fe3O4) as synergistic agents for NIR-induced
PTT. In this study, phase-shift and NIR photoabsorbing poly(lactic-co-glycolic acid) (PLGA) nanocapsules (perfluorohexane (PFH)@PLGA/Fe3O4) were fabricated for MRI/US dual-modal imaging-guided
PTT. The multifunctional nanocapsules can be used not only to increase
the local tumor temperature by absorbing the NIR energy but also as
bimodal contrast agents for both MRI and US imaging. Such nanocapsules
can be converted into microbubbles under NIR irradiation, which produces
excellent contrast for US imaging and enhanced cancer ablation. We
refer to the nanocapsule phase transition process induced by the infrared
lamp as NIR radiation droplet vaporization (NIRDV).
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bimodal contrast agentsNIR energyMRISuch nanocapsulesPhotothermal TherapyNIR irradiationnanocapsules encapsulating superparamagnetic iron oxideheat energynanocapsule phase transition processPTTNIRDVimagingFe 3OPLGAphotothermal conversion reagentsPFHcancer ablationNIR radiation droplet vaporizationcancer treatmentmultifunctional nanocapsulestissue penetrationtumor temperature
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