es9b01068_si_001.pdf (1.03 MB)
Particulate Matter Exposure History Affects Antioxidant Defense Response of Mouse Lung to Haze Episodes
journal contribution
posted on 2019-08-02, 11:38 authored by Xuemei Liu, Jinhua Wang, Yifan Fan, Yue Xu, Mengxing Xie, Yu Yuan, Huiming Li, Xin QianFew
studies have focused on the association between previous particulate
matter (PM) exposure and antioxidant defense response to a haze challenge.
In this study, a combined exposure model was used to investigate whether
and how PM exposure history affected the antioxidant defense response
to haze episodes. At first, C57BL/6 male mice were randomly assigned
to three groups and exposed for 5 weeks to whole ambient air, ambient
air containing a low (≤75 μg/m3) PM concentration,
and filtered air, which simulated different exposure history of high,
relatively low, and almost zero PM concentrations. Thereafter, all
mice underwent a 3-day haze exposure followed by a 7-day exposure
to filtered air. The indexes involved in the primary and secondary
antioxidant defense response were determined after pre-exposure and
haze exposure, as well as 1 day, 3 days, and 7 days after haze exposure.
Our research demonstrated repeated exposure to a high PM concentration
compromised the antioxidant defense response and was accompanied by
an increased susceptibility to a haze challenge. Conversely, mice
with a lower PM exposure developed an oxidative stress adaption that
protected them against haze challenge more efficiently and in a more
timely manner than was the case in mice without PM exposure history.