Palladium(II)-Catalyzed Intramolecular Aminobromination and Aminochlorination of Olefins
journal contributionposted on 08.11.2004 by Maria R. Manzoni, Thomas P. Zabawa, Dhanalakshmi Kasi, Sherry R. Chemler
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The first intramolecular aminobromination and aminochlorination of olefins catalyzed by palladium(II) is reported. These reactions use a stoichiometric amount of copper(II) halide salt to aid in halogen transfer and catalyst oxidation. The yields are generally high and the degree of regioselectivity (endo vs exo cyclization) varies with substrate structure. Control experiments were performed to determine the requirements for a catalytic reaction. Solvent, temperature, and the nature of the copper halide salt all effect the course of the reaction.