jo202060k_si_001.pdf (3.03 MB)
Palladium-Catalyzed Direct Arylation of Polysubstituted Benzofurans
journal contribution
posted on 2012-02-03, 00:00 authored by Amandine Carrër, Dimitri Brinet, Jean-Claude Florent, Patricia Rousselle, Emmanuel BertounesqueAn efficient access to 2-substituted 3-arylbenzofurans
through
a palladium-catalyzed C3 direct arylation of 2-substituted benzofurans
with aryl bromides is described. The scope and limitation of this
reaction was studied. The method tolerates a variety of functional
groups on the aryl halide and has been successfully extended to polysubstituted
benzofurans to obtain the corresponding 3-arylbenzofurans with good
to excellent yields.