ol5b02422_si_001.pdf (3.88 MB)
Palladium-Catalyzed Decarboxylative Ortho-Ethoxycarbonylation of O‑Methyl Ketoximes and 2‑Arylpyridines with Potassium Oxalate Monoester
journal contribution
posted on 2015-10-02, 00:00 authored by Zhong-Yuan Li, Guan-Wu WangA novel method for introducing an
ester group via palladium-catalyzed
ligand-directed C–H activation has been explored. The ortho-ethoxycarbonylation of O-methyl ketoximes
proceeded smoothly with the nontoxic and easily handled reagent potassium
oxalate monoester, affording the desired products in moderate to good
yields. Furthermore, pyridine could also be employed as a directing
group to obtain similar results in this transformation.