ol5b00214_si_001.pdf (6.43 MB)
Palladium-Catalyzed Carbonylative Cyclization of Aryl Alkenes/Alkenols: A New Reaction Mode for the Synthesis of Electron-Rich Chromanes
journal contribution
posted on 2015-03-06, 00:00 authored by Shuang Li, Fuzhuo Li, Jianxian Gong, Zhen YangThe
Pd(II)-catalyzed intramolecular carbonylative cyclization reaction
of aryl alkenes and aryl alkenols is reported for the synthesis of
structurally diverse chromanes. PdCl2(CH3CN)2 was used as the catalyst and CuCl2 as the oxidant
under the balloon pressure of CO. The reaction is conducted under
mild conditions, and chromane-type esters and lactones can be generated
in a highly regio- and stereoselective manner.