ol501389k_si_001.pdf (2.19 MB)
Palladium-Catalyzed α‑Arylation of Sultams with Aryl and Heteroaryl Iodides
journal contribution
posted on 2014-07-03, 00:00 authored by Olivier René, Benjamin P. Fauber, Sushant Malhotra, Herbert YajimaPalladium(0)-catalyzed conditions
for the α-arylation of
sultams with aryl and heteroaryl iodides have been developed. Arylation
of 3-substituted 1,3-propanesultams gave rise to high yields and high
diastereomeric ratios, leading to the thermodynamically favored cis product. The arylation was broadly applicable to various
electron-rich and electron-poor (hetero)aromatic iodides.
