Palladium-Catalyzed α‑Arylation of Sultams with Aryl and Heteroaryl Iodides
2014-07-03T00:00:00Z (GMT) by
Palladium(0)-catalyzed conditions for the α-arylation of sultams with aryl and heteroaryl iodides have been developed. Arylation of 3-substituted 1,3-propanesultams gave rise to high yields and high diastereomeric ratios, leading to the thermodynamically favored cis product. The arylation was broadly applicable to various electron-rich and electron-poor (hetero)aromatic iodides.