ol026408d_si_001.pdf (84.68 kB)
Palladium-Promoted Cascade Reactions of Isonitriles and 6-Iodo-N-propargylpyridones: Synthesis of Mappicines, Camptothecins, and Homocamptothecins
journal contribution
posted on 2002-08-20, 00:00 authored by Dennis P. Curran, Wu DuAmbient-temperature reactions of electron-rich aryl isonitriles with substituted 6-iodo-N-propargylpyridones in the presence of silver carbonate
and palladium acetate produce 11H-indolizino[1,2-b]quinolin-9-ones in good to excellent yield. Experimental evidence suggests that the process
occurs though organopalladium rather than radical intermediates. It is applied to synthesis analogues of mappicine and camptothecin, including
the silatecans DB-67 and DB-91 (homo-DB-67).