ol6b01038_si_002.cif (21.55 kB)
Palladium-Catalyzed Regioselective Difluoroalkylation and Carbonylation of Alkynes
dataset
posted on 2016-05-18, 00:00 authored by Qiang Wang, Yu-Tao He, Jia-Hui Zhao, Yi-Feng Qiu, Lan Zheng, Jing-Yuan Hu, Yu-Chen Yang, Xue-Yuan Liu, Yong-Min LiangA novel, four-component synthetic
strategy to synthesize a series
of β-difluoroalkyl unsaturated esters/amides
with high regioslectivity is described. This Pd-catalyzed difluoroalkylation
and carbonylation reaction can be carried out with simple starting
materials. Through this protocol, two new C–C bonds (including
one C–CF2 bond) and one C–O(N) bond are constructed
simultaneously in a single step. The synthetic utility of this reaction
system has been certified by the applicability to a wide scope of
alkynes and nucleophiles. Preliminary mechanistic studies suggest
that the difluoroalkyl radical pathway is involved in this reaction.