Palladium-Catalyzed Asymmetric Intramolecular Dearomative Heck Reaction of Pyrrole Derivatives

The Pd-catalyzed asymmetric intramolecular dearomatization of pyrroles via the Heck reaction in the presence of commercially available Pd­(OAc)₂ and the Feringa ligand is described. Diverse pyrroline derivatives were obtained in excellent yields (up to 99%) with high enantioselectivity (up to 96% ee). The reaction features a wide substrate scope, relatively mild conditions, and useful transformations of the products.