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PPh3 Mediated Reductive Annulation Reaction between Isatins and Electron Deficient Dienes to Construct Spirooxindole Compounds
journal contribution
posted on 2017-05-15, 00:00 authored by Lei Zhang, Hong Lu, Guo-Qiang Xu, Zhu-Yin Wang, Peng-Fei XuA PPh3 mediated reductive annulation reaction between
isatins and 4,4-dicyano-2-methylenebut-3-enoates was developed. The
reaction provided an alternative method for constructing five- and
three-membered all-carbon spirooxindole compounds. Lithium chloride
as a Lewis acid played a key role in the synthesis of spirocyclopentenyl
oxindole compounds.
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alternative methodLewis acidPPh 3spirocyclopentenyl oxindole compoundsreductive annulation reactionPPh 3 Mediated Reductive Annulation Reactionrolesynthesisthree-membered all-carbon spirooxindole compoundsSpirooxindole CompoundsLithium chloridedicyano-2-methylenebutisatinElectron Deficient DienesIsatin
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