Oxidative Nucleophilic Cyclization of 2‑Alkynylanilines with Thiophenols under Metal-Free Conditions
2014-12-19T00:00:00Z (GMT) by
An oxidative nucleophilic cyclization of 2-alkynylanilines with thiophenols under metal-free conditions was developed. The one-pot two-step reaction involves a PhI(OAc)2-mediated oxidative dearomatization and a Brønsted acid promoted nucleophilic cyclization. DFT calculations were performed to understand the reaction pathway.
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