American Chemical Society
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Oxidative Cyclorelease from Soluble Polymeric Supports

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journal contribution
posted on 2005-05-13, 00:00 authored by Hua Liu, Shuangyi Wan, Paul E. Floreancig
Single electron oxidation is shown to be a viable method for effecting concomitant cyclization and cleavage (cyclorelease) of a series of polymer bound homobenzylic ethers. Soluble oligonorbornene polymers are stable toward redox chemistry and are isolable through precipitation with methanol, making them excellent supports for this process. These oxidative conditions are also shown to cleave secondary and tertiary alcohols and ethers in a new traceless approach to polymer-supported aldehyde and ketone synthesis.

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