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Oxidative Coupling of Indoles with Ethyl 2‑(Disubstituted Amino)Acetates: An Approach to Achieve Indolylglycine Derivatives
journal contribution
posted on 2012-08-17, 00:00 authored by Zhanwei Xu, Xiaoqiang Yu, Xiujuan Feng, Ming BaoAn efficient method for the synthesis of indolylglycine
derivatives
is described. The oxidative coupling reactions of ethyl 2-(disubstituted
amino)acetates with indoles proceeded smoothly in the presence of meta-chloroperoxybenzoic acid (mCPBA) under
ambient conditions to produce indolylglycine derivatives in satisfactory
to excellent yields.