jo500145w_si_001.cif (57.21 kB)
Organocatalyzed Enantioselective Mannich Reaction of Pyrazoleamides with Isatin-Derived Ketimines
dataset
posted on 2014-05-16, 00:00 authored by Tian-Ze Li, Xi-Bo Wang, Feng Sha, Xin-Yan WuThe first organocatalytic enantioselective
Mannich reaction of
pyrazoleamides with isatin-derived N-Boc ketimines
has been developed to afford 2-oxindole-based chiral β-amino
amides in good yields (84–97%) with excellent diastereo- and
enantioselectivities (up to 99:1 dr and >99% ee).