Organocatalyzed Enantioselective
Mannich Reaction
of Pyrazoleamides with Isatin-Derived Ketimines

Li, Tian-Ze; Wang, Xi-Bo; Sha, Feng; Wu, Xin-Yan

doi:10.1021/jo500145w.s002

jo500145w_si_002.pdf (1.06 MB)

Organocatalyzed Enantioselective Mannich Reaction of Pyrazoleamides with Isatin-Derived Ketimines

journal contribution

posted on 2014-05-16, 00:00 authored by Tian-Ze Li, Xi-Bo Wang, Feng Sha, Xin-Yan Wu

The first organocatalytic enantioselective Mannich reaction of pyrazoleamides with isatin-derived N-Boc ketimines has been developed to afford 2-oxindole-based chiral β-amino amides in good yields (84–97%) with excellent diastereo- and enantioselectivities (up to 99:1 dr and >99% ee).