co4001259_si_003.cif (28.97 kB)
One-Pot Synthesis of Coumarin-3-carboxamides Containing a Triazole Ring via an Isocyanide-Based Six-Component Reaction
dataset
posted on 2014-04-14, 00:00 authored by Shabnam Shaabani, Ahmad Shaabani, Seik Weng NgA facile,
efficient, and environmentally friendly approach has been developed
for the diversity oriented synthesis of trifunctional coumarin-amide-triazole
containing compounds. A wide variety of pharmacologically significant
and structurally interesting compounds were synthesized via a one-pot,
six-component, tandem Knoevenagel/Ugi/click reaction sequence from
readily available starting materials in ethanol at room temperature
in excellent overall yields. Substituents could be independently varied
at five different positions.