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One-Pot Synthesis of Diphenylalanine-Based Hybrid Nanospheres for Controllable pH- and GSH-Responsive Delivery of Drugs
journal contribution
posted on 2016-08-25, 00:00 authored by Qiuju Li, Min Chen, Daoyong Chen, Limin WuNano drug delivery systems have attracted
much research and clinical
interest but they remain challenging with respect to developing controllable,
nontoxic, biocompatible and biodegradable nanocarriers. Herein, we
report the first pH- and glutathione (GSH)-responsive diphenylalanine
(FF)-based hybrid spheres using natural alginate dialdehyde (ADA)
as the cross-linker to induce self-assembly of FF and an in
situ reducer of Au3+ ions into Au nanoparticles
(Au NPs). Not only is the synthesis simple and high-yielding, but
also these biocompatible hybrid spheres can encapsulate more than
95% of hydrophobic drug (camptothecin, CPT). Moreover, the CPT-loaded
carriers are stable under normal physiological environments, and have
excellent pH- and GSH-responsive release at pH 5.0 with 10 mM GSH,
which is similar to the tumor microenvironment. Also, these nanocarriers
can be taken up by cancer cells and have greater cytotoxicity than
free drugs. These attributes make nanospheres very promising for drug
loading and delivery, and the method may be used for synthesis of
other natural nanospheres as delivery systems.
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FFnanocarrieralginate dialdehydeDrugs Nano drug delivery systemsNPGSH-Responsive DeliveryCPT-loaded carrierstumor microenvironment10 mM GSHControllable pHcancer cellsbiocompatibledrug loadingnanosphereADADiphenylalanine-Based Hybrid NanospheresGSH-responsive releaseOne-Pot SynthesissynthesispH 5.0delivery systems
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