om9b00575_si_001.pdf (1.85 MB)
One-Pot, One-Step Precatalysts through Mechanochemistry
journal contribution
posted on 2019-10-16, 14:33 authored by Thomas
E. Shaw, Logesh Mathivathanan, Titel JurcaThe development and implementation
of transition-metal-based precatalysts
have played crucial roles in modern organic synthesis. However, while
the use of such species greatly improves sustainability, their preparative
routes often rely on multiple time-, energy-, and solvent-intensive
steps. By leveraging solvent-free mechanochemical synthesis through
vibratory ball milling, we report the one-pot, one-step synthesis
of a range of first-row transition-metal bis(imino)pyridine complexes,
where both the ligand and coordination complex are assembled in situ.
Bis(imino)pyridine complexes of the first-row transition metals have
an extensive history of application as precatalysts for numerous bond-forming
transformations. The method reported herein facilitates access to
such species in a time-, solvent-, and space-saving manner which can
easily be adapted to any laboratory setting regardless of prior experience
with coordination complex synthesis.