On the Structure of Total Synthesis of Complex Natural Products

1998-10-06T00:00:00Z (GMT) by H. W. Whitlock
A chemically intuitive measure (metric) for molecular complexity is described. It is then applied to several syntheses of complex natural products. We conclude that the metric corresponds well with chemical ideas of complexity, and that different syntheses do in fact have appreciably different logical structures as measured by this. Possible implications of this interesting observation are discussed.