jo011054+_si_001.pdf (86.14 kB)
Novel Sesquiterpenoids from the Fermentation of Xylaria persicaria Are Selective Ligands for the NPY Y5 Receptor
journal contribution
posted on 2002-06-14, 00:00 authored by Cameron J. Smith, Nancy R. Morin, Gerald F. Bills, Anne W. Dombrowski, Gino M. Salituro, Scott K. Smith, Annie Zhao, Douglas J. MacNeilNeuropeptide Y (NPY) is a polypeptide found in
the peripheral and central nervous system and is involved
in the regulation of feeding. Antagonists of NPY receptor
activation could therefore have potential for development
as antiobesity drugs. Fermentation of an isolate of Xylaria
persicaria yielded two novel eremophilane sesquiterpenoids
xylarenals A (1) and B (2). These compounds are selective
for the NPY Y5 receptor but have only modest affinity. The
isolation, structure elucidation, and biological activities of
these compounds are described.