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Novel Platform for Surface-Mediated Gene Delivery Assisted with Visible-Light Illumination
journal contribution
posted on 2020-04-01, 14:42 authored by Lili Yao, Wenjian Weng, Kui Cheng, Liming Wang, Lingqing Dong, Jun Lin, Kuang ShengSurface-mediated
gene delivery has attracted more and more attentions in biomedical
research and applications because of its characteristics of low toxicity
and localized delivery. Herein, a novel visible-light-regulated, surface-mediated
gene-delivery platform is exhibited, arising from the photoinduced
surface-charge accumulation on silicon. Silicon with a pn junction
is used and tested subsequently for the behavior of surface-mediated
gene delivery under visible-light illumination. It is found that positive-charge
accumulation under light illumination changes the surface potential
and then facilitates the delivery of gene-loaded carriers. As a result,
the gene-expression efficiency shows a significant improvement from
6% to 28% under a 10 min visible-light illumination. Such improvement
is ascribed to the increase in surface potential caused by light
illumination, which promotes both the release of gene-loaded carriers
and the cellular uptake. This work suggests that silicon with photovoltaic
effect could offer a new strategy for surface-mediated, gene-delivery-related
biomedical research and applications.
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surface-mediated gene-delivery platformSurface-Mediated Gene Delivery Assistedlight illumination changes10 min visible-light illuminationresearchapplicationsiliconVisible-Light Illumination Surface-mediated gene deliverysurface-mediated gene deliveryphotoinduced surface-charge accumulationgene-loaded carriers
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