Novel One-Step Synthesis of Thiazolo[3,2-b]1,2,4-triazoles

Reactions of chalcones 3af with bis(1H-1,2,4-triazolyl) sulfoxide 4 formed the thiazolo[3,2-b]1,2,4-triazoles 5af, which resemble closely some previously prepared COX-2 inhibitors. The structure of 5a was confirmed by X-ray analysis.