ol990370w_si_001.pdf (176.85 kB)
Novel One-Step Synthesis of Thiazolo[3,2-b]1,2,4-triazoles
journal contribution
posted on 2000-02-02, 00:00 authored by Alan R. Katritzky, Alfredo Pastor, Michael Voronkov, Peter J. SteelReactions of chalcones 3a−f with bis(1H-1,2,4-triazolyl) sulfoxide 4 formed the thiazolo[3,2-b]1,2,4-triazoles 5a−f, which resemble closely some
previously prepared COX-2 inhibitors. The structure of 5a was confirmed by X-ray analysis.