American Chemical Society
Browse
ol990370w_si_001.pdf (176.85 kB)

Novel One-Step Synthesis of Thiazolo[3,2-b]1,2,4-triazoles

Download (176.85 kB)
journal contribution
posted on 2000-02-02, 00:00 authored by Alan R. Katritzky, Alfredo Pastor, Michael Voronkov, Peter J. Steel
Reactions of chalcones 3af with bis(1H-1,2,4-triazolyl) sulfoxide 4 formed the thiazolo[3,2-b]1,2,4-triazoles 5af, which resemble closely some previously prepared COX-2 inhibitors. The structure of 5a was confirmed by X-ray analysis.

History