Novel Method for Synthesizing Spiro[4.5]cyclohexadienones through a Pd-Catalyzed Intramolecular ipso-Friedel−Crafts Allylic Alkylation of Phenols
journal contributionposted on 05.11.2010 by Tetsuhiro Nemoto, Yuta Ishige, Mariko Yoshida, Yuta Kohno, Mutsumi Kanematsu, Yasumasa Hamada
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The first successful Pd-catalyzed intramolecular ipso-Friedel−Crafts allylic alkylation of phenols, which provided a new access to spiro[4.5]cyclohexadienones, is described. The present method could be applied to catalytic enantioselective construction of an all-carbon quaternary spirocenter.