ol500444z_si_001.pdf (3.1 MB)
Nitroepoxides as Versatile Precursors to 1,4-Diamino Heterocycles
journal contribution
posted on 2014-03-21, 00:00 authored by Andreu Vidal-Albalat, Santiago Rodríguez, Florenci V. GonzálezNitroepoxides
are easily transformed into 1,4-diamino heterocycles
such as quinoxalines and pyrazines by treatment with 1,2-benzenediamines
and ammonia, respectively. Additionally, related saturated heterocycles,
such as piperazines and tetrahydroquinoxalines, can be accessed by
treatment with 1,2-diamines and a reducing agent. These transformations
are efficient, provide access privileged, bioactive structures, and
produce minimal waste.