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Nickel-Catalyzed Defluorinative Reductive Cross-Coupling Reaction of gem-Difluoroalkenes with Thiosulfonate or Selenium Sulfonate
journal contribution
posted on 2019-08-28, 14:03 authored by Jian Li, Weidong Rao, Shun-Yi Wang, Shun-Jun JiA nickel-catalyzed defluorinative
reductive cross-coupling of gem-difluoroalkenes with
thiosulfonate or selenosulfonates
is described. The reaction involves the formation of thiolated or
selenylated monofluoroolefins via regioselective C–F bond cleavage
and C–S or C–Se bond formation and features easily available
substrates, mild reaction conditions, and high E-selectivity.
One of the derivatives by further cross coupling with PhMgBr exhibited
an aggregation-induced emission enhancement effect.
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reaction conditionsselenosulfonateselectivityNickel-Catalyzed Defluorinative Reductive Cross-Coupling ReactionThiosulfonatethiolatedregioselectiveSelenium Sulfonatedifluoroalkenederivativethiosulfonateselenylated monofluoroolefinsformationPhMgBrgemsubstrateDifluoroalkeneaggregation-induced emission enhancement effectnickel-catalyzed defluorinative reductive cross-couplingcleavagebond
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