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New Trichothecenes Isolated from Holarrhena floribunda
journal contribution
posted on 1999-12-04, 00:00 authored by Ali Loukaci, Oliver Kayser, K.-U. Bindseil, Karsten Siems, J. Frevert, Pedro M. AbreuBioassay-guided fractionation of an extract of Holarrhena floribunda stem, has led to the isolation of the
new trichothecenes, 8-dihydrotrichothecinol A (1), loukacinol A (2), and loukacinol B (3), and the known
compounds, trichothecolone (4), trichothecin (5), trichothecinol A (6), rosenonolactone (7), 6β-hydroxyrosenonolactone (8), and rosololactone (9). The structures were determined by spectral and chemical
methods, and absolute configurations were established by a modified Horeau's method using HPLC.
Compounds 1 and 6 exhibited significant cytotoxicity against several human tumor cell lines, whereas
compound 8 showed moderate and weak antileishmanial activity toward extracellular and intracellular
Leishmania donovani, respectively.
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compound 8rosololactonefractionationrosenonolactoneCompounds 1antileishmanial activityintracellular Leishmania donovaniNew TrichothecenestrichothecinHPLCcytotoxicitytumor cell linestrichothecolonedihydrotrichothecinolconfigurationtrichothecenetrichothecinolhydroxyrosenonolactoneloukacinol BisolationextracellularHoreauHolarrhena floribundachemical methods
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