ol502603f_si_002.cif (32.55 kB)
New Cytotoxic Naphthohydroquinone Dimers from Rubia alata
dataset
posted on 2014-11-07, 00:00 authored by Si-Meng Zhao, Zhe Wang, Guang-Zhi Zeng, Wei-Wu Song, Xiao-Qiang Chen, Xiao-Nian Li, Ning-Hua TanTwo novel naphthohydroquinone dimers
with unprecedented skeletons,
rubialatins A (1) and B (2), were isolated
from the herbal plant Rubia alata together with their
precursor, mollugin (3). The structures were elucidated
on the basis of NMR spectra and crystal X-ray diffraction. Compound 1, a racemate, was separated by chiral column chromatography,
and the absolute configurations of the enantiomers were determined
by the computational methods. Cytotoxicity of 1–3 was evaluated as well as the effect on the NF-κB pathway.
Compound (+)-1 showed cytotoxicity and could inhibit
NF-κB pathway. Meanwhile, 2 showed cytotoxicity
and a synergistic effect with TNF-α on NF-κB activation.