New Class
of Betulinic Acid-Based Nanoassemblies of
Cabazitaxel, Podophyllotoxin, and Thiocolchicine

Colombo, Eleonora; Polito, Laura; Biocotino, Michele; Marzullo, Paola; Hyeraci, Mariafrancesca; Via, Lisa Dalla; Passarella, Daniele

doi:10.1021/acsmedchemlett.9b00668.s001

ml9b00668_si_001.pdf (217.31 kB)

New Class of Betulinic Acid-Based Nanoassemblies of Cabazitaxel, Podophyllotoxin, and Thiocolchicine

journal contribution

posted on 2020-03-04, 18:44 authored by Eleonora Colombo, Laura Polito, Michele Biocotino, Paola Marzullo, Mariafrancesca Hyeraci, Lisa Dalla Via, Daniele Passarella

Betulinic acid is validated as a new self-assembly inducer for the formation of nanoparticles (NPs) in combination with different drugs. The target compounds are characterized by the presence of anticancer drugs acting on tubulin dynamics and of a linker that could be a carbon chain or a triazole-based one. Nanoparticles formed are characterized and their biological activity is evaluated.