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Near-Infrared Light-Triggered Drug-Delivery Vehicle for Mitochondria-Targeted Chemo-Photothermal Therapy
journal contribution
posted on 2014-03-26, 00:00 authored by Enguo Ju, Zhenhua Li, Zhen Liu, Jinsong Ren, Xiaogang QuA novel drug-delivery vehicle for
mitochondria-targeted chemo-photothermal
therapy was demonstrated. A cytochrome c-specific
binding aptamer was employed to make the mesoporous silica-encapsulated
gold nanorods efficiently accumulate in the mitochondria of cancer
cells. This nanocarrier can load various hydrophobic therapeutic agents
acting on mitochondria to enhance the therapeutic efficiency and simultaneously
depress the toxic side effects. In addition, near-IR treatment could
induce cytochrome c release and initiation of the
mitochondrial pathway of apoptosis. Importantly, this multifunctional
platform could integrate targeting, light-triggered release, and chemo-photothermal
therapy into one system. We hope that such a system could open the
door to the fabrication of a multifunctional mitochondria-targeted
drug-delivery vehicle for cancer therapy.